Journal: British Journal of Pharmacology

Article Title: Glutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research

doi: 10.1111/bph.13919

Figure Lengend Snippet: Impact of NMDA receptor coagonists and partial agonists on cognition

Article Snippet: Neumeister et al., 2006 , N/A , , HCs 12 (8:4) 28.5(±10.5) , , Double‐blind, randomized, balanced cross‐over study design Two separate drug challenge sessions (placebo/active drug): Glycine: 200 mg·kg −1 body weight for 45 min i.v. Placebo: saline , Neuropsychological testing outside of PET scanner: CogState computerized battery ( i.e. attention, visual, verbal and working memory, executive function, speed of processing) , Effect of glycine on cognitive performance: No significant effect of glycine on any of the neuropsychological tests compared to placebo Effect of glycine on PET measures: Decreased whole‐brain cerebral metabolic rate of glucose (CMRGlu) in glycine treated HCs when compared to placebo Decreased rCMRGlu in cerebellum and DLPFC without whole‐brain correction (ROI analysis).

Techniques: Control, Battery, Blocking Assay, Saline

Journal: International Journal of Critical Illness and Injury Science

Article Title: Neuropsychological and behavioral benefits of virtual cognitive rehabilitation training among pediatric population surviving malaria: A systematic review and meta-analysis

doi: 10.4103/ijciis.ijciis_74_24

Figure Lengend Snippet: Study characteristics included in review

Article Snippet: Boivin MJ et al ., 2019[ ] , To evaluate the effects of CCRT for alleviating persisting neurocognitive deficits in Ugandan severe malaria survivors , 150 school-aged children with severe malaria and 150 non-malaria children were randomised to three treatment arms: A limited CCRT arm that did not titrate to proficiency but instead alternated randomly between the easiest to medium level of training; and a passive control arm. The Captain’s Log CCRT arm consisted of 24 sessions and targeted attention, working memory, and nonverbal reasoning , KABC, 2 nd ed..ition Computerized CogState cognitive tests Behaviour rating inventory for executive function Achenbach Child Behaviour Checklist , Cognitive processing index ( P =0.04), Sequential thinking (working memory) ( P =0.02), and the concepts understanding subtest (planning/reasoning) ( P =0.02) all showed significant improvements compared to inactive controls. In comparison to passive controls, CogState card identification (attention) ( P =0.02) and the BRIEF global executive index improved one year after training ( P =0.01). Alone the KABC-II concept thinking (both full- and limited-CCRT; P =0.01), CogState Groton maze chase and acquisition ( P =0.01), and CogState card recognition ( P =0.05, full-CCRT only) tests significantly improved for non-malaria children undergoing CCRT , Due to the increased repetition and practice on pertinent training in the absence of performance titration for full CCRT, restricted CCRT for severe malaria survivors enhanced attention and memory outcomes far beyond full CCRT.

Techniques: Control, Battery, Comparison, Titration, Infection, Clinical Proteomics